Transgender young adults and families with transgender youth, together with PFLAG National and GLMA, filed a federal legal challenge against a January 2025 executive order from the Trump administration directing federal agencies to withhold funds from medical providers and institutions that provide gender-affirming medical treatments for people under nineteen.

A family in Texas had a child welfare investigator arrive at their home due to a directive from Governor Greg Abbott stating that health care that is medically necessary for treating gender dysphoria should be considered a form of child abuse. This family — an employee of DFPS, her husband, and their transgender teen — sued Governor Abbott and the Texas Department of Family and Protective Services. Dr. Megan Mooney, a licensed psychologist who works with transgender youth and their families, also joined the lawsuit.

In May 2025, two transgender adolescents and their parents filed a challenge in Kansas state court against SB 63, a state law prohibiting access to gender-affirming medical treatments for transgender people under 18. Access to gender-affirming medical care, such as hormone therapies and pubertal suppressants, for transgender adolescents is supported by the American Medical Association, the American Psychological Association, and the American Academy of Pediatrics.

The North Carolina Department of Public Safety has continually denied Kanautica Zayre-Brown, an incarcerated transgender woman in their custody, access to gender-affirming surgery.