The American Civil Liberties Union, ACLU of Maryland, and Capital Area Immigrants’ Rights (CAIR) Coalition filed a federal lawsuit on April 30, 2020, challenging the Trump administration’s failure to provide fair hearings to people in immigration detention. The case was filed on behalf of immigrants in detention in Maryland, but challenges policies that apply nationwide.

On March 24, 2020, the ACLU National Prison Project, ACLU Immigrants’ Rights Project, the ACLU of Maryland, the National Immigration Project of the National Lawyers Guild, and the Capital Area Immigrants Rights (CAIR) Coalition filed Coreas v. Bounds on behalf of immigrants detained at Immigrations and Customs Enforcement (ICE) facilities in Maryland.

On October 20, 2017 the ACLU, the ACLU of Maryland, and Free State Justice intervened on behalf of James van Kuilenburg, a transgender student, in the case Smith v. Board of Education of Frederick County to defend a Maryland school board’s policies that prevent discrimination, harassment, and stigmatization of transgender and gender nonconforming students in the school system.

Whether states can be sued under the "self-care" provision of the Family and Medical Leave Act (FMLA) for failing to provide employees with twelve weeks unpaid leave to deal with their own medical needs.