On March 29, 2018, the American Civil Liberties Union, the American Civil Liberties Union of Ohio, and Lambda Legal filed a lawsuit challenging Ohio’s refusal to correct the gender marker on birth certificates for transgender people, for any reason, at any time. Ohio is one of just three states, with Tennessee and Kansas, that has yet to change the extremely regressive and harmful policy. The lawsuit states that the Ohio government has violated the equal protection, due process, and free speech rights of Stacie Ray, Basil Argento, Ashley Breda, and a fourth, unnamed plaintiff.

Evan Minton was turned away from a Dignity Health hospital because he is transgender. He filed a lawsuit against a Dignity Health medical center for withholding medical care because of a patient's gender identity, amounting to sex discrimination in violation of California's Unruh Civil Rights Act.

The American Civil Liberties Union (ACLU), the American Civil Liberties Union of Florida, and DLA Piper LLP filed a federal lawsuit challenging the Florida Department of Corrections’ (DOC) denial of medically necessary care for Reiyn Keohane, a transgender woman currently detained in a men’s prison.

The ACLU, ACLU of Maryland, and Covington & Burling LLP filed a lawsuit against the Trump administration on behalf of six members of the armed forces who are transgender and the ACLU of Maryland. The lawsuit challenges the president’s directive banning transgender service members from continuing to serve in the military, banning transgender service members from receiving certain medically necessary health care, and banning transgender individuals from enlisting in the armed forces.