In the spring of 2023, Texas became the largest state in the country to ban gender-affirming care for transgender youth after Governor Greg Abbott signed SB 14. In July 2023, a lawsuit was filed on behalf of five Texas families, three medical professionals, and two organizations representing hundreds of families and health professionals across the state. The five Texas families challenging this law come from diverse backgrounds across the state with transgender children and teenagers. The bill’s passage alone resulted in families splitting up or planning to leave Texas to continue treatment for their children. The families are suing pseudonymously to protect themselves and their children, who are transgender Texans between the ages of 9 and 16.

Three transgender people currently incarcerated in federal custody have filed a class action lawsuit against the Trump Administration and the Federal Bureau of Prisons (BOP) challenging an Executive Order and new BOP policies prohibiting their access to gender-affirming care. The class action lawsuit was filed in federal court in Washington, D.C., on behalf of approximately 2,000 transgender people incarcerated in federal prisons across the United States.

The North Carolina Department of Public Safety has continually denied Kanautica Zayre-Brown, an incarcerated transgender woman in their custody, access to gender-affirming surgery.

Transgender young adults and families with transgender youth, together with PFLAG National and GLMA, filed a federal legal challenge against a January 2025 executive order from the Trump administration directing federal agencies to withhold funds from medical providers and institutions that provide gender-affirming medical treatments for people under nineteen.