On April 11, 2024, the ACLU, ACLU of Southern California, ACLU of Northern California, and ACLU of San Diego & Imperial Counties filed an amicus brief with the California Court of Appeal, Fifth Appellate District supporting the California Civil Rights Department’s appeal of a lower court judgment finding that a bakery owner did not violate the California public accommodations law when she refused to sell a wedding cake to a same-sex couple.

On February 15, 2024, the ACLU and ACLU of Montana filed an amicus brief urging the U.S. Court of Appeals for the Ninth Circuit to leave in place an injunction against enforcement of a Montana law that infringes minors’ First Amendment rights by restricting their ability to attend drag performances.

On January 23, 2019, the American Civil Liberties Union, and the American Civil Liberties Union of Arizona filed a class action lawsuit against the State of Arizona and the Arizona Board of Regents for denying medically necessary, gender-affirming health care to transgender people employed by the state. The lawsuit was filed on behalf of Dr. Russell B. Toomey, an associate professor of family studies and human development at the University of Arizona, and all other transgender individuals employed by the Arizona Board of Regents or enrolled in the State health plan, including dependents.

Eden Rogers and Brandy Welch were turned away by a government-funded foster care agency for failing to meet the agency’s religious criteria which exclude prospective foster parents who are not evangelical Protestant Christian or who are same-sex couples of any faith.