On Thursday, August 18, 2022 the ACLU, ACLU of Florida, Legal Defense Fund and Ballard Spahr filed a lawsuit challenging Florida's HB7 (aka the Stop W.O.K.E. Act) on behalf of a group of Florida educators and students in higher education.

On August 18, 2022 the American Civil Liberties Union, along with 12 ACLU state affiliates and represented by Cooley LLP, filed an amicus brief with the U.S. Supreme Court urging the court to uphold the constitutionality of the Indian Child Welfare Act.

On May 28, 2022 the American Civil Liberties Union filed an amicus brief with the Supreme Court in a case, Fitisemanu v. United States, addressing the constitutionality of the federal law designating persons born in American Samoa as “non-citizen U.S. nationals.”

In the latest front in the nationwide fight against criminalization of poverty and, specifically, debtors' prisons, on June 1, 2017, the ACLU's Racial Justice Program, the ACLU of South Carolina, and Terrell Marshall Law Group PLLC filed a federal lawsuit challenging the illegal arrest and incarceration of indigent people in Lexington County, South Carolina, for failure to pay fines and fess, without determining willfulness or providing assistance to counsel. Those targeted by this long-standing practice can avoid jail only if they pay the entire amount of outstanding court fines and fees up front and in full. Indigent people who are unable to pay are incarcerated for weeks to months without ever seeing a judge, having a court hearing, or receiving help from a lawyer. The result is one of the most draconian debtors’ prisons uncovered by the ACLU since 2010.

Whether civil rights statutes that prohibit federal financial recipients from discriminating on the basis of disability, race, and sex allow plaintiffs to be compensated for emotional distress injuries where they show that they were victims of discrimination.